USA Biology Olympiad (USABO) Practice Exam

A mutation in the gene encoding cyclin D can lead to what possible outcomes?

1. It has no effect on the cell cycle.

2. It may lead to cancer.

3. It can cause apoptosis.

4. Any of the above.

The correct answer is: Any of the above.

A mutation in the gene encoding cyclin D can lead to a variety of outcomes due to its crucial role in the regulation of the cell cycle. Cyclin D is an essential protein involved in the transition from the G1 phase to the S phase of the cell cycle, where DNA is replicated. If a mutation occurs in the cyclin D gene, it can potentially disrupt the normal function of cyclin D. This can result in several scenarios. For instance, if the mutation leads to the production of a dysfunctional cyclin D, it may affect cell cycle progression, possibly resulting in an arrest of the cycle or uncontrolled cell division, which is often associated with the development of cancer. Additionally, aberrant levels or activity of cyclin D can interfere with apoptosis, the programmed cell death mechanism, which could also contribute to tumorigenesis if cells that should die continue to survive and proliferate. Conversely, some mutations might have negligible effects, allowing the cell cycle to continue unharmed. In summary, the mutation in the gene encoding cyclin D can indeed lead to no effect, promote oncogenesis (cancer), or influence apoptotic pathways, reflecting the versatility of outcomes related to this important regulatory protein in cell cycle control.